Kliniske undersøgelser

Siden 2008 er Cefaly’s effektivitet blevet bevist gennem en lang række kliniske undersøgelser. Resultaterne er blevet udgivet i anerkendte videnskabelige tidsskrifter, f.eks. Neurology og Cephalalgia.

The Journal of Headache and Pain, December 2013:

Delphine Magis, Simona Sava, Tullia Sasso d’Elia, Roberta Baschi and Jean Schoenen: Safety and patients’ satisfaction of transcutaneous Supraorbital NeuroStimulation (tSNS) with the Cefaly device in headache treatment: a survey of 2,313 headache sufferers in the general population

Cephalalgia 2013; Volume 33, Number 8 (Supplement) June 2013:

D. Magis: “Safety and Efficiency of Neurostimulation with the Cefaly Device for Headache Treatment: Outcome of a Prospective Registry on 2,313 Patients”

Cephalalgia, June 27-30, 2013:

International Headache Society and American Headache Society: “Abstracts of the 2013 International Headache Congress”

Neurology February 19, 2013, vol. 80 no. 8 697-704:

Schoenen, Vandersmissen, Jeangette, Herroelen, Vandenheede, Gérard and Magis: “Migraine prevention with a supraorbital transcutaneous stimulator: a randomized controlled trial”

BMC Neurology, 2011, Oct 28; 11: 135:

Piquet M, Balestra C, Sava SL, Schoenen J: “Supraorbital transcutaneous neurostimulation has sedative effects in healthy subjects”

Cephalalgia 2010, Mar; 30 (3): 260-71.:

Reed KL, Black SB, Banta CJ 2nd, Will KR: “Combined occipital and supraorbital neurostimulation for the treatment of chronic migraine headaches” 

Cephalalgia 2009; 29: 134:

Gérardy PY, Fabry D, Fumal A, Schoenen J: “A pilot study on supra-orbital surface electrotherapy in migraine”


Videnskabelige artikler

Op til 2008, hvor Cefaly første gang kom på markedet i udlandet, er flere videnskabelige undersøgelser blevet gennemført på smerteklinikker, universitetshospitaler og specialiserede laboratorier over hele verden. Samlet set er der inkluderet mere end 5000 behandlinger med Cefaly i undersøgelserne, med henblik på at validere Cefaly’s effektivitet.

Herunder findes artikler med relation til neuromodulation, som er princippet bag Cefaly. Neuromodulation har været genstand for forskning siden 1960′erne, og er i årtier blevet brugt til smertebehandling samt behandling af en lang række andre lidelser. Læs mere om neuromodulation på The International Neuromodulation Society’s hjemmeside.

Artiklerne herunder er oplistet i kronologisk rækkefølge.

Curr Pain Headache Rep. 2008 Jan;12(1):62-6:

Schwedt TJ: “Occipital nerve stimulation for medically intractable headache”

Pain Physician. 2008 Mar-Apr;11(2):253-6:

Trentman TL, Dodick DW, Zimmerman RS, Birch BD: “Percutaneous occipital stimulator lead tip erosion: report of 2 cases”

J Clin Psychiatry. 2008 Mar;69(3):412-7:

Bystritsky A, Kerwin L, Feusner J: “A pilot study of cranial electrotherapy stimulation for generalized anxiety disorder”

Cephalalgia. 2008 Apr;28(4):355-9. Epub 2008 Feb 14:

Amin S, Buvanendran A, Park KS, Kroin JS, Moric M: “Peripheral nerve stimulator for the treatment of supraorbital neuralgia: a retrospective case series”

Pain Pract. 2008 Mar-Apr;8(2):120-4. Epub 2008 Jan 7:

Asensio-Samper JM, Villanueva VL, Pérez AV, López MD, Monsalve V, Moliner S, De Andrés J.: “Peripheral neurostimulation in supraorbital neuralgia refractory to conventional therapy.”

Acta Neurochir Suppl. 2007;97(Pt 1):115-20:

Slavin KV.: “Peripheral nerve stimulation for the treatment of neuropathic craniofacial pain.”

Headache. 2007 Jul-Aug;47(7):1100-2:

Narouze SN, Kapural L.: “Supraorbital nerve electric stimulation for the treatment of intractable chronic cluster headache: a case report.”

Expert Rev Neurother. 2007 Dec;7(12):1785-9:

Goadsby PJ.: “Neurostimulation in primary headache syndromes.”

Epilepsia. 2006 Jul;47(7):1213-5:

DeGiorgio CM, Shewmon A, Murray D, Whitehurst T.: “Pilot study of trigeminal nerve stimulation (TNS) for epilepsy: a proof-of-concept trial.”

Neurosurgery. 2006 Jan;58(1):112-9; discussion 112-9:

Slavin KV, Nersesyan H, Wess C.: “Peripheral neurostimulation for treatment of intractable occipital neuralgia.”

Neurosurg Focus. 2006 Dec 15;21(6):E5:

Slavin KV, Colpan ME, Munawar N, Wess C, Nersesyan H.: “Trigeminal and occipital peripheral nerve stimulation for craniofacial pain: a single-institution experience and review of the literature.”

Neurosurgery. 2004 Jul;55(1):135-41; discussion 141-2:

Johnson MD, Burchiel KJ.: “Peripheral stimulation for treatment of trigeminal postherpetic neuralgia and trigeminal posttraumatic neuropathic pain: a pilot study.”

Neurology. 2003 Aug 12;61(3):421-2:

DeGiorgio CM, Shewmon DA, Whitehurst T.: “Trigeminal nerve stimulation for epilepsy.”

Arch Physiol Biochem. 2001 Oct;109(4):304-8:

Holsheimer J.: “Electrical stimulation of the trigeminal tract in chronic, intractable facial neuralgia.” Basic publications

Headache. 2007 Jul-Aug;47(7):1100-2:

Narouze SN, Kapural L.: “Supraorbital nerve electric stimulation for the treatment of intractable chronic cluster headache: a case report.

Cochrane Database Syst Rev. 2004;(3):CD001878:

Bronfort G, Nilsson N, Haas M, Evans R, Goldsmith CH, Assendelft WJ, Bouter LM.: Review: “Non-invasive physical treatments for chronic/recurrent headache.”

Headache. 2004 Apr;44(4):333-41:

“Electroacupuncture for tension-type headache on distal acupoints only: a randomized, controlled, crossover trial”

Neurol Sci. 2003 May;24 Suppl 2:S138-42:

“Non-pharmacological approaches to chronic headaches: transcutaneous electrical nerve stimulation, lasertherapy and acupuncture in transformed migraine treatment”

Cochrane Database Syst Rev. 2001;(3):CD003222:

“Transcutaneous electrical nerve stimulation (TENS) for chronic pain”

Headache. 1999 Jul-Aug;39(7):502-5:

“Use of percutaneous electrical nerve stimulation (PENS) for treating ECT-induced headaches”

Headache. 2000 Apr;40(4):311-5:

“Use of percutaneous electrical nerve stimulation (PENS) in the short-term management of headache”

CMAJ. 1997 May 1;156(9):1273-87:

“Guidelines for the diagnosis and management of migraine in clinical practice. Canadian Headache Society”

Ann Ital Chir. 1997 Jul-Aug;68(4):505-9:

“The treatment of cranio-facial pain by electroacupuncture and laser irradiation”

J Tradit Chin Med. 1995 Jun;15(2):124-6 202:

“Cases of headache treated with electroacupuncture”

Ann Acad Med Singapore. 1995 Jan;24(1):17-22:

“The use of transcutaneous electrical nerve stimulation (TENS) in the treatment of facial pain”

Headache. 1989 Jul;29(7):445-50:

“Safety and effectiveness of cranial electrotherapy in the treatment of tension headache”

Headache. 1989 Mar;29(3):156-62:

“The effectiveness of physical therapy in the treatment of chronic daily headaches”

Headache. 1989 Jan;29(1):34-41:

“Non-invasive treatment of vascular and muscle contraction headache: a comparative longitudinal clinical study”

Psychiatr Neurol Med Psychol (Leipz). 1988 Dec;40(12):717-23:

“Punctate transcutaneous electrical nerve stimulation in migraine therapy”

Headache. 1986 Sep;26(8):431-3:

“Headache and cervical spine disorders: classification and treatment with transcutaneous electrical nerve stimulation”

Headache. 1985 Jan;25(1):12-5:

“Treatment of headache by transcutaneous electrical stimulation”

Phys Ther. 1984 Sep;64(9):1367-74:

“Effect of transcutaneous electrical nerve stimulation on human blood beta-endorphin levels”

Res Clin Stud Headache 2: 29-59 (1969):

Anthony, M, Hinterberger, H, Lance, JW: “The possible relationship of serotonin to the migraine syndrome”

Cephalalgia 15 : 277-280 (1995):

Buzzi, MG, Bonamini, M, Moskowitz, MA: “Neurogenic model of migraine”

Pain 19: 259-275 (1984a):

Chung, JM, Fang, ZR, Hori, Y, Lee, KH, Willis, WD: “Prolongated inhibition of primate spinothalamic tract cells by peripheral nerve stimulation”

Pain 19: 277-293. (1984b):

Chung, JM, Lee, KH, Hori, Y, Endo, K, Willis, WD: “Factors influencing peripheral nerve stimulation produced inhibition of primate spinothalamic tract cells”

Cephalalgia 13 : 151-165 (1993):

Ferrari, MD, Saxena, PR: “On serotonin and migraine: a clinical and pharmacological review”

Médecine-Sciences 9 : 21-30 (1993):

Hamon, M, Gozlan, H: “Les récepteurs centraux de la sérotonine”

Physical Therapy 58 : 1467-1473 (1978):

Howson, D: “Peripheral neural excitability. Implications for transcutaneous electrical nerve stimulation”

Journal of Neurosurgery 45 : 159-165 (1976):

Ignelzi, RJ, Nyquist, JK: “Direct effect of electrical stimulation on peripheral nerve evoked activity implications in pain relief”

Physical Therapy 74: 951-962 (1994):

Kantor, G, Alon, G, Ho, H: “The effects of selected stimulus waveforms on pulse and phase characteris-tics at sensory and motor thresholds”

Brain 117 : 199-210 (1994):

Lauritzen, M: “Pathophysiology of the migraine aura. The spreading depression theory”

Science 150: 971-979 (1965):

Melzack, R, Wall, P: “Pain mechanisms: A new theory”

Electroencephalography and Clinical Neurophysiology. 74 : 24-35 (1989):

Nardone, A, Schieppati, M: “Influences of transcutaneous electrical stimulation of cutaneous and mixed nerves on subcortical and cortical somatosensory evoked potentials”

Ann Med Interne 143 : 173-183 (1992):
Ollat, H, Bousser, MG: “Physiopathogénie de la migraine”

Science 164: 444-445. (1969):
Reynolds, DV: “Surgery in the rat during electrical analgesia induced by focal brain stimulation”

Science 155: 108-109. (1967):
Wall, PD, Sweet, WH: “Temporary abolition of pain in man”

Ny forskning understøtter effekten af Cefaly.

I tidsskriftet Cephalalgia er der lige offentliggjort en artikel der viser at regelmæssig brug af Cefaly ændrer stofskiftet i hjernens pandelapper.
Studiet er lave ved hjælp af PET-scanninger.